The investigation of the glycobiology of dissected glioblastoma human brain tissue

PhD student Ugne Kuliesiute

1. Established collaboration between Vilnius University and the University of Freiburg.
2. Acquired the state-of-the art human organotypic brain slice culture technique.
3. Acquired preliminary data on sialylation of human glioblastoma.

1. Established collaboration between Vilnius University and the University of Freiburg, joined meetings were held online allowing sharing interdisciplinary experience.
2. Transferred knowledge on state-of-the art human organotypic brain slice culture technique, Freiburg, Germany.
3. Identified changes of sialic acid turnover, sialic acid’s role in the functional activity of human glioblastoma cells and the expression level of four human sialidases in healthy and glioblastoma infiltrated human brain tissue, Freiburg, Germany.
4. Participation in The 12^th Conference of the Lithuanian Neuroscience Association were Ms. Ugne Kuliesiute presented the results of this project and Dr. Dieter Henrik Heiland presented research carried out by the Microenvironment and Immunology Research Laboratory at the University of Freiburg, Department of Neurosurgery. The forum was held online.

Dr. Vidhya Madapusi Ravi will participate and Dr. Dieter Henrik Heiland, M.D. will participate in The 12^th Conference of the Lithuanian Neuroscience Association (November 6, 2020, Life Sciences Center, Lithuania), presenting their research as guest speakers.

Direct: PhD student Ugne Kuliesiute, PD Dr. Dieter Henrik Heiland, Dr. Vidhya Madapusi Ravi and the members of Microenvironment and Immunology Research Laboratory at the University of Freiburg, Department of Neurosurgery (10 members).

Indirect: The members of Molecular Neurobiology group at the Life Sciences Center of Vilnius University (10 members). Participants of The 12^th Conference of the Lithuanian Neuroscience Association (audience of app. 200 people).