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+ 371 67286033
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Project title Modern trends in solid-state NMR and spin dynamics: towards non-destructive polarizing agents
Time of implementation 01.06. - 30.11.2018
Involved countries and institutions

1. Vilnius University (Lithuania)

2. University of Technology (Germany)
Aim(s) of the project In recent years, the combination of high-resolution solid-state NMR and high-field Dynamic Nuclear Polarization (DNP), a novel hyperpolarization technique, has evolved into a major spectroscopic tool for the investigation of “real world” systems, e.g. biomaterials. In DNP, the sample of interest should include species that contain one or more unpaired electrons. Then the microwave irradiation causes simultaneous forbidden electron spin and nuclear spin transitions which increase the nuclear spin polarization of nearby nuclei. Usually, polarization is transferred to protons but in principle could be transferred to any NMR active nuclei of interest. Due to efficient proton spin diffusion process the polarization is then transferred to NMR active nuclei of interest via conventional Cross-Polarization (CP) or related techniques. This allows achieving signal enhancement of the order of 102. These days the main challenge DNP face is tailoring the technique to the systems of interest. The most popular approach is to use the dissolution DNP when the sample is placed in glass forming matrix. Nevertheless, the presence of the solvent can lead to unwanted changes in the properties of the system. In order to avoid this, we propose to:

1) systematically investigate the building blocks (amino acids) of the peptides for the purpose to choose the target ones for preparing radical peptide;

2) investigate the synthesized radical peptides for the purpose to employ them for DNP NMR spectroscopy.

Additionally, during the meeting in Vilnius the German collaborators will give a set of lectures, seminars and practical exercises. This is a good opportunity for students and researches from Vilnius University to deepen their knowledge in solid state NMR and DNP spectroscopy. What is more, the results of the current project will be disseminated to a wider target audience by Lithuanian and German project partners.

Target group

Direct: Vilnius NMR group, TU-Darmstadt NMR group. Approx. 15 people


Indirect: Students and Researches at Vilnius University. Approx. 50 people

Main activities of the project and venue(s) where the project activities will be carried out:

1. NMR experimental work, Vilnius University

 

2. Interim meeting and low temperature NMR experimental work, TU–Darmstadt

 

3. DNP experimental work, TU–Darmstadt

 

4. Lectures and final meeting, Vilnius University

Public events in the frame of the project 1. Lectures and discussions at Vilnius University

2. Practical seminars and exercises for the students from the Faculties of Physics, Chemistry and Geosciences, and the Centre of Life Sciences. (08.-11.10.2018)

11. October 2018

Auditorium 401, building 3, Sauletekio aleja 9, Faculty of Physics, Vilnius, Lithuania

Seminar and Project Meeting 

Program and Lecturer